EST applications in bioinorganic chemistry

Bioinorganic chemistry

Transition metal ions have key enabling features for modern society. Fortunately they can be measured by ESR, being a key enabling technique for development of production processes, standard and research applications. Applications of MS5000 ESR spectrometer reaching from biochemistry, medical application throughout chemical characterisation.

Advantages of ESR/EPR spectrometer MS5000

  • High sensitivity and spectrometer stability also for aqueous samples due to powerful automatic spectrometer self-adjustment routines

  • Auto-sampler for efficient routine investigations

  • Measurement and user interface parameter setting by recipes for extremely easy handling of routine measurements, also by unskilled persons 

  • Automatic time- dependent and transient EPR- measurements in timescales from 2µs time- resolution to hours or days

  • g- value representation of EPR spectra

  • Very high reproducibility of EPR line positions by automatic microwave-frequency readjusted magnetic field scale

  • X- ray irradiation facility (accessory, option)

Protective e€ects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion

Occlusion of the splanchnic circulation followed by reperfu-sion (SAO) results in a severe form of circulatory shock,characterized by severe hypotension, hemoconcentration,intestinal injury and a high mortality rate (Lefer & Lefer,1993; Zimmermann et al., 1993).

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ESR Identification of Free Radicals Formed from the Oxidation of Catechol Estrogens by Cu2+

Catechol estrogens are genotoxic, indirectly through redox cycling mechanisms leading to oxidative DNA damage and directly by formation of quinone–DNA adducts. Previously, we demonstrated that Cu2/ can oxidize estradiol (E2) catechols, establishing a copper redox cycle leading to the formation of DNA strand breaks. 

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