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Electrical semiconductor characterization
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Free radical measurements in life science and biomedical applications
Our benchtop MiniScope (MS 5000) ESR spectrometer is a research grade device with sensitivity and reliability for demanding...
Industry standard for evaluating irradiation doses on alanine tablets
Nitric oxide measurement, reactive oxygen species, oxidative stress, radical generating systems, photo dynamic therapy
Analysis of chemical structure of paramagnetic centers and their orientation within a crystal
Bioinorganic transition metal compounds, fenton chemistry, effect of heavy metal ions on livving tissue
Variety of free radicals in environmental applications can be evaluated by EPR spectroscopy
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Spin trapping technique using MS5000 EPR/ESR spectrometer is a standard application to determine the oxygen concentration in living tissue.
EPR signals are broadened with increasing oxygen concentration. Appliyng a apramagnetic oxygen sensor, the measurement of local quantities of oxygen is carried out within minutes. Suspensions of charcoal allow observation at any place a liquid could reach.
Bernard Gallez, Bénédicte F. Jordan, Nicolas Christian, Nathalie Crokart, Vincent Grégoire, Olivier Feron (2007) - Thyroid Status is a Key Modulator of Tumor Oxygenation: Implication for Radiation Therapy. Radiation Research 168, 428-432
Gallez et al. (2007) name the rate of oxygen consumption as a "key factor" to estimate the effect of radiation therapy on tumor cells. In healthy tissue, hormones such as thyroid stimulate oxygen consumption. Therefore, an analogous effect on tumors was hypothezised.
Experimental tumors and their close environment were observed to see if changes in the thyroid concentration effects their metabolic activity. EPR oximetry revealed a significant change of the oxygen concentration with varying thyroid status. Thus, oxygen consumption was altered tremendously. As expected, tumor's regrowth was dealyed by lowering thyroid activity.
"This study provides unique insights into the impact of modulating tumor oxygen consumption and could have implications in the management of cancer patients with thyroid disorders."