Disease in relation to oxidative stress

The level of ROS is a key indicator for illness. By monitoring these species, ESR spectroscopy enables new methods of treating diseases like cancer or diabetes.

Cancer Cachexia

 

In modern medicine, cancer treatment faces major obstacles besides the tumor itself. Many cancer patients suffer from cachexia, a constant state of significant weightloss and weakness. An elevated level of uric acid (UA) leads to higher production rates of reactive oyxgen species (ROS)  depending on xanthine oxidase (XO) activity. Once the degradation products of UA expand into the serum, metabolic illnes will worsen the patient’s condition tremendously.

The presented study applies xanthine-inhibitors to reduce UA level. XO-activity was monitored by ESR spectroscopy.

Results

Treatment with either of two XO-inhibitors, decreased waitloss and tissue wasting. Degradation on a cellular level through ROS was lessened by XO-inhibition.