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The level of ROS is a key indicator for illness. By monitoring these species, ESR spectroscopy enables new methods of treating diseases like cancer or diabetes.
Nadine Moeller, Jochen Springer, Anika Tschirner, Kai Hartman, Sandra Palus, Eva K. Wirth, Silvia Busquets Ruis, Stephan von Haehling, Josep M. Argiles, Josef Koehrle, Volker Adams, Stefan D. Anker and Wolfram Doehner (2012) Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia. International Journal of Cancer 131, 2187-2196
In modern medicine, cancer treatment faces major obstacles besides the tumor itself. Many cancer patients suffer from cachexia, a constant state of significant weightloss and weakness. An elevated level of uric acid (UA) leads to higher production rates of reactive oyxgen species (ROS) depending on xanthine oxidase (XO) activity. Once the degradation products of UA expand into the serum, metabolic illnes will worsen the patient’s condition tremendously.
The presented study applies xanthine-inhibitors to reduce UA level. XO-activity was monitored by ESR spectroscopy.
Treatment with either of two XO-inhibitors, decreased waitloss and tissue wasting. Degradation on a cellular level through ROS was lessened by XO-inhibition.