Reactive oxygen species (ROS)

Free radicals are chemical species of high oxidative potential that can damage the human body on a cellular level. They can be detected by ESR applying a fast, simple and sensitive measurement.

Background

Human beings and animals exhale nitric oxdie (NO), which is formed in the nasal cavities and lungs. A pathological status such as inflammation is expressed by higher NO output. Also, the inner human body as well as single-cell organisms are confronted with peroxyl- and hydroxyl-radicals, so-called oxidative stress.

 

To explore causes and production mechanisms of these species, ESR is applied to detect these oxygen-derived radicals inside living tissue. Today's Life Science is driven by the search for a fundamental understanding of life's degrading and renewing processes. With the help of the MS 5000, this can be found.

Spin trapping of nitric oxide

  • "catching" short-lived radicals for specific measurement

  • spin traps: NO cheletropic traps, colloid Fe(II)(DETC)2

Fenton reaction

While observing free radicals in human blood, a peculiar formation mechanism is revealed.

Diseases related to oxidative stress

pulmonary hypertension, diabetes, cancer