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Electrical semiconductor characterization
Luminescence dating, research, dosimetry and more
Free radical measurements in life science and biomedical applications
Our benchtop MiniScope (MS 5000) ESR spectrometer is a research grade device with sensitivity and reliability for demanding...
The MS 6000 is a research device with high-end sensitivity for sophisticated applications in field of science & technology.
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Nitric oxide measurement, reactive oxygen species, oxidative stress, Proteine structure & enzyme function
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A variety of free radicals is formed through pollutants such as particulate matter, nanoparticles or others
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The level of ROS is a key indicator for illness. By monitoring these species, ESR spectroscopy enables new methods of treating diseases like cancer or diabetes.
Nadine Moeller, Jochen Springer, Anika Tschirner, Kai Hartman, Sandra Palus, Eva K. Wirth, Silvia Busquets Ruis, Stephan von Haehling, Josep M. Argiles, Josef Koehrle, Volker Adams, Stefan D. Anker and Wolfram Doehner (2012) Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia.International Journal of Cancer 131, 2187-2196
In modern medicine, cancer treatment faces major obstacles besides the tumor itself. Many cancer patients suffer from cachexia, a constant state of significant weightloss and weakness. An elevated level of uric acid (UA) leads to higher production rates of reactive oyxgen species (ROS) depending on xanthine oxidase (XO) activity. Once the degradation products of UA expand into the serum, metabolic illnes will worsen the patient’s condition tremendously.
The presented study applies xanthine-inhibitors to reduce UA level. XO-activity was monitored by ESR spectroscopy.
Treatment with either of two XO-inhibitors, decreased waitloss and tissue wasting. Degradation on a cellular level through ROS was lessened by XO-inhibition.
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